瘤微环境驱动瘤透淋巴细胞中的共刺激和抑制分子之间的交叉对话:优化免疫治疗结果的含义
1Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
International journal of molecular sciences
|December 17, 2024
概括
本综述研究了抗瘤T细胞的反应,重点关注免疫检查点 (IC) 和其阻断 (ICB) 疗法. 了解TME的复杂性是改善患者的治疗结果和克服对癌症治疗的耐药性的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 瘤微环境 (TME) 极大地影响T细胞的反应,平衡激活和疲劳.
- 瘤利用抑制性免疫检查点 (IC) 逃避免疫监测,影响癌症的进展.
- 免疫检查点阻塞 (ICB) 疗法已经彻底改变了癌症治疗,但面临的挑战是患者的反应率和耐药性.
研究的目的:
- 审查抗瘤T细胞反应的复杂机制.
- 突出TME内共刺激和抑制途径之间的相互作用.
- 强调需要预测生物标志物和ICB耐药性的组合疗法.
主要方法:
- 关于T细胞免疫学和癌症免疫治疗的文献综述.
- 分析瘤微环境在免疫逃避中的作用.
- 探索共刺激和抑制路径交叉交谈的探索.
主要成果:
- 在TME中,T细胞的反应是由共刺激和抑制信号的复杂平衡调节的.
- 癌细胞利用IC抑制抗瘤免疫力,导致T细胞耗尽.
- 患者对ICB的有限反应强调了需要更深入地了解TME动态的需要.
结论:
- 识别免疫分子之间的关键交叉对话对于有效的癌症免疫疗法至关重要.
- 根据患者特定的个人资料量身定制疗法可以提高ICB的疗效.
- 对TME复杂性的进一步研究对于改善癌症患者的临床结果至关重要.
相关概念视频
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:27Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
01:27Cytotoxic T Cells-mediated Immune Response
844
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
844