特纳综合征和甲状腺功能-一个系统和批判性审查
Katarzyna Lacka1, Nikola Pempera2, Alicja Główka2
1Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
International journal of molecular sciences
|December 17, 2024
概括
患有特纳综合征 (TS) 的女性患甲状腺疾病的发病率更高,包括甲状腺功能低下症和自身免疫性甲状腺疾病. 定期进行甲状腺查对于TS患者的早期检测和治疗至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 这是一种自身免疫力.
背景情况:
- 特纳综合征 (TS) 是一种遗传疾病,与甲状腺疾病的患病率相比,甲状腺疾病的患病率要高得多.
- 了解TS中的特定甲状腺异常对于有效的患者管理至关重要.
研究的目的:
- 系统地审查和批判性地评估特纳综合征患者的甲状腺功能和自身免疫力.
- 评估在TS群体中甲状腺疾病和相关标记物的患病率.
主要方法:
- 在PubMed,Scopus,Google Scholar和Cochrane图书馆进行了全面的文献搜索,截至2024年7月.
- 关键词包括"特纳综合征"",自身免疫性甲状腺疾病"",TSH"",甲状腺功能低下"",抗TPO"和"抗Tg".
- 分析了甲状腺刺激激素 (TSH),三甲状腺素 (TT3) 和甲状腺素 (fT4,TT4) 水平的数据,以及甲状腺抗体和超声检测结果.
主要成果:
- 甲状腺疾病在特纳综合征患者中非常普遍.
- 患有TS的女性表现出TSH水平升高,甲状腺抗体的阳性频率更高.
- 典型的甲状腺超声波发现包括具有低原性或混合性声波模式的异质性.
结论:
- 早期和持续监测甲状腺激素水平对于及时诊断和治疗TS的甲状腺功能低下症至关重要.
- 作者建议对特纳综合征患者实施结构化甲状腺查计划,以防止诊断不足并确保及时的治疗干预.
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