Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Model for the Development of Alzheimer's Disease.

Genomics, proteomics & bioinformatics·2025
Same author

BloodProST: prediction of blood-secretory proteins through self-training.

Briefings in bioinformatics·2025
Same author

Computational analyses to reveal the key determinants of the high malignancy level of cholangiocarcinoma.

Journal of translational internal medicine·2025
Same author

Optimizing Model Performance and Interpretability: Application to Biological Data Classification.

Genes·2025
Same author

Elucidation of Factors Affecting the Age-Dependent Cancer Occurrence Rates.

International journal of molecular sciences·2025
Same author

Construction of a Dataset for All Expressed Transcripts for Alzheimer's Disease Research.

Brain sciences·2025
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
查看所有相关文章

相关实验视频

Updated: Jun 4, 2025

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

8.2K

深度增强器PPO:一种可解释的深度学习方法用于增强器分类.

Xuechen Mu1,2, Zhenyu Huang2,3, Qiufen Chen4

  • 1School of Mathematics, Jilin University, Changchun 130012, China.

International journal of molecular sciences
|December 17, 2024
PubMed
概括
此摘要是机器生成的。

深度增强器PPO是一种新的深度学习模型,准确地分类增强器的类别和优势. 这种方法通过提高增强剂分类准确性和可解释性来增强我们对基因调节的理解.

关键词:
这就是PPO PPO PPO.这就是ResNet ResNet.增强器的分类是加强器的分类.可以解释的解释性.变压器的变压器是一个变压器.

更多相关视频

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.6K
Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

9.3K

相关实验视频

Last Updated: Jun 4, 2025

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

8.2K
AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

2.6K
Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

9.3K

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 机器学习 机器学习

背景情况:

  • 增强剂是调节基因表达的关键非编码基因组元素.
  • 目前用于分类增强剂类别和强度的方法有限.
  • 准确的增强剂分类对于理解转录调节至关重要.

研究的目的:

  • 开发一种新的深度学习模型,用于准确的增强器分类.
  • 改进增强器类别和监管优势的分类.
  • 提高增强剂分类结果的解释性.

主要方法:

  • 提出了DeepEnhancerPPO,一个端到端的深度学习架构.
  • 集成的ResNet和变压器模块用于特征提取.
  • 使用近距离政策优化 (PPO) 来减少特征维度.

主要成果:

  • 在独立数据集上,DeepEnhancerPPO实现了卓越的性能.
  • 在增强器类别分类准确度方面,超过现有模型的表现为6.7%.
  • 证明了强大的增强剂强度分类,排名在顶级分类器中.

结论:

  • 深度增强器PPO为增强器分类提供了一个强大而准确的框架.
  • 该模型通过改进的分类来增强对基因调节的理解.
  • 靠近政策优化提高了性能和可解释性.