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非结合性T63变异在IL-18结合中的作用

Chariya Peeyatu1, Napat Prompat1, Supayang Piyawan Voravuthikunchai2

  • 1Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

International journal of molecular sciences
|December 17, 2024
PubMed
概括

改造Thr63的工程介质素-18 (IL-18) 影响蛋白质的灵活性和结合部位. 这项研究为通过基于结构的药物设计开发基于IL-18的新型疗法提供了洞察力.

关键词:
介质蛋白-18的使用方法互乐金-18受体的受体是什么分子动力学模拟模拟突变发生点突变发生点.蛋白质构成的结构.蛋白质动力学 蛋白质动力学

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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