子宫内膜异位症对体外受精结果的影响:系统性审查和元分析
Ilenia Mappa1, Zoe Pauline Page1, Daniele Di Mascio2
1Department of Obstetrics and Gynecology, Fondazione Policlinico di Tor Vergata, University of Rome Tor Vergata, 00133 Roma, Italy.
Healthcare (Basel, Switzerland)
|December 17, 2024
概括
子宫内膜异位症对接受体外受精 (IVF) 的女性的植入率产生负面影响. 然而,活产,临床怀孕和受精的试管婴儿成功率仍然不受子宫内膜异位症的影响.
科学领域:
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
- 妇科健康 妇科健康
背景情况:
- 子宫内膜异位症是一种常见的妇科疾病,影响生育年龄的女性.
- 它对体外受精 (IVF) 结果的影响是正在进行的研究和临床辩论的主题.
- 了解这些影响对于优化生育治疗至关重要.
研究的目的:
- 系统地审查和元分析子宫内膜异位症对体外受精 (IVF) 关键结果的影响.
- 评估对活产率,临床怀孕率,受精率和植入率的影响.
- 为接受试管婴儿治疗的子宫内膜异位症患者管理提供基于证据的见解.
主要方法:
- 在多个数据库 (PubMed,MEDLINE,Embase等) 中进行全面的系统搜索. 从2010年1月开始到2023年11月.
- 包括比较IVF结果在女性内膜异位症和没有内膜异位症的研究.
- 使用几率比率 (OR) 和95%置信区间 (CI) 来评估治疗效果的元分析.
主要成果:
- 分析了40项涉及8,970名子宫内膜异位症妇女和42,946名对照妇女的研究.
- 在活产率 (OR 1.03),临床怀孕率 (OR 0.86) 或受精率 (OR 0.96) 中没有发现显著差异.
- 在患有子宫内膜异位症的女性中,发现植入率的统计显著降低 (OR 0.85,p=0.02).
结论:
- 子宫内膜异位症与体外受精周期中的植入率显著降低有关.
- 活产,临床怀孕和受精率不受子宫内膜异位症的显著影响.
- 进一步的研究是有必要的,以探索子宫内膜异位症阶段的影响,并制定量身定制的试管婴儿协议.
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