危急疾病中的低酸血症:叙述性审查
Mahesh Ramanan1,2,3,4, Alexis Tabah1,5, Julia Affleck2
1Faculty of Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Journal of clinical medicine
|December 17, 2024
概括
低酸盐水平的低酸血是重症监护室 (ICU) 患者中常见的. 虽然酸盐补充是安全的,但它对重症患者的益处仍然不确定,需要进一步研究.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 临床营养学 临床营养学
背景情况:
- 酸盐是一个关键的细胞内离子,对细胞功能至关重要.
- 低酸血症是重症患者常见的电解质障碍,影响了高达75%的重症监护室 (ICU) 住院患者.
- 现有的关于低血和ICU结局之间的关联的文献是相互矛盾的,容易产生混因素.
研究的目的:
- 审查在重症患者中低酸血症的管理.
- 总结目前在ICU中酸盐补充的最佳实践.
- 确定关键的研究重点,关于纠正低血的临床效用.
主要方法:
- 在危急疾病中对低酸血的文献综述.
- 对酸盐 (肠道和静脉注射) 的当前指导方针和证据的分析.
- 讨论以患者为中心的结果和研究差距.
主要成果:
- 通过肠道和静脉输入的酸盐被认为是安全的在ICU设置.
- 纠正低血症的临床益处和潜在危害,特别是轻度病例,尚未得到充分证实.
- 在将低血症与ICU结局联系起来的研究中存在显著的混.
结论:
- 虽然安全,但在危急疾病期间低酸盐血症中酸盐补充的最终以患者为中心的好处需要进一步调查.
- 对于ICU患者中轻度或低正常酸盐水平的最佳管理策略仍然存在不确定性.
- 进一步的研究是必不可少的,以澄清酸盐补充剂在改善重症患者的治疗结果中的作用和有效性.
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