慢性肝病患者的多种疾病:西班牙EpiChron队列中的基于人口的研究,西班牙
Aída Moreno-Juste1,2,3, Beatriz Poblador-Plou1,3, Clara Laguna-Berna1,3
1EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain.
Journal of clinical medicine
|December 17, 2024
概括
在慢性肝病 (CLD) 患者中,多病症很常见,平均有13种疾病. 一个全面的,以人为中心的方法对于管理这些复杂的案件至关重要.
科学领域:
- 肝病学和内科医学.
- 临床流行病学临床流行病学
- 老年医学 老年医学
背景情况:
- 由于发病率和死亡率的上升,慢性肝病 (CLD) 构成了重大的临床挑战.
- 了解CLD患者同时出现的疾病的全部范围对于有效管理至关重要.
研究的目的:
- 为了全面描述诊断为慢性肝病的成年患者的多病症模式.
- 确定与CLD相关的特定共发病和多发病群.
主要方法:
- 使用2015年EpiChron队列 (西班牙) 数据进行的回顾性观察研究.
- 分析6836名成人CLD患者的并发症,包括后勤回归和探索性因子分析.
- 评估CLD与110种慢性疾病之间的关联,根据年龄和性别进行调整.
主要成果:
- 平均而言,CLD患者有13种同时存在的慢性疾病,其中高血压,脂质疾病,糖尿病,肥胖和肌肉骨疾病是最常见的.
- 在110个分析的慢性疾病中,有75个与CLD显著相关,特别是慢性胰腺炎 (OR 41.2) 和遗传代谢障碍 (OR 14.9).
- 出现了三种不同的多病态模式:心血管,代谢老年和精神物质使用,以及一些基于性别的变化.
结论:
- 对于患有慢性肝病的人来说,多病症是标准,而不是例外.
- 临床实践需要一个整体的,以人为中心的护理模式,以解决CLD患者广泛的并发症.
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