探索维生素B水平与代谢综合征风险之间的联系:哈萨克斯坦病例控制研究的见解
Alma Nurtazina1,2, Ivan Voitsekhovskiy3, Maxat Toishimanov4
1Department of Epidemiology and Biostatistics, Semey Medical University, Semey 071400, Kazakhstan.
Journal of clinical medicine
|December 17, 2024
概括
维生素B2水平升高,即使在正常范围内,也与哈萨克斯坦人口中代谢综合征 (MS) 风险增加有关. 这一发现突出了B族维生素的重要性.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 线粒体生物学 线粒体生物学
背景情况:
- 代谢综合征 (MS) 影响全球20-30%的成年人,其特点是胰岛素抵抗,肥胖,脂质失调和高血压.
- 线粒体功能障碍,包括mtDNA突变和改变的动态,是MS发病的一个关键因素,损害了葡萄糖氧化.
- 维生素B对线粒体功能和代谢健康至关重要,在MS的背景下尤其重要.
研究的目的:
- 研究血B族维生素度与发生代谢综合征的风险之间的关联.
- 分析哈萨克斯坦人口中关于代谢综合征患病率的B族维生素状况.
主要方法:
- 一项涉及190名哈萨克斯坦成年人 (35-65岁) 患有 (n=104) 和没有 (n=86) 多发性硬化症的病例控制研究.
- 生物化学测量包括血清禁食葡萄糖,HbA1c,肌素,脂质样本和血B维生素水平.
- 在2022年12月至2024年3月期间在Semey综合诊所收集的数据.
主要成果:
- 大多数参与者维生素B3 (95.77%) 和维生素B6 (76.02%) 的水平较低.
- 在95%的参与者中,维生素B2水平处于正常水平的下限,其中4.59%的维生素B2水平较低.
- 在正常范围内较低的维生素B2含量显著与MS风险增加有关 (OR=1.79,95% CI 1.003-3.19,p=0.05).
结论:
- 维生素B2,即使在正常范围的下端,也与患上代谢综合征的风险明显增加有关.
- 这些发现强调了维生素B在代谢健康和MS预防中的重要性.
- 对在不同人群中预防MS的最佳B族维生素水平进行进一步的研究是有必要的.
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