在患有后急性COVID-19的患者中,内皮糖异常和眼部表现
Georges Azar1, Youssef Abdelmassih1, Sophie Bonnin1
1Rothschild Foundation Hospital, 75019 Paris, France.
Journal of clinical medicine
|December 17, 2024
概括
后急性COVID-19患者表现出视网膜和胆道血管问题,包括毛细血管非 perfusion. 眼部病理与毛细血管密度降低有关,这表明微血管干扰是主要原因.
科学领域:
- 眼科医生 眼科 眼科
- 微血管医学是一种微血管医学.
- 传染病并发症 传染病并发症
背景情况:
- COVID-19可能导致长期健康问题,包括眼部表现.
- 了解后急性COVID-19对微血管系统的影响对于患者管理至关重要.
研究的目的:
- 调查COVID-19后急性患者的眼科和微血管变化.
- 为了将眼部发现与特定的微血管参数相关联.
主要方法:
- 44名患有后急性COVID-19和眼科症状的患者的前性单心队列研究.
- 使用了绿色血管学 (ICGA),OCT,OCT血管学,自适应光学和GlycoCheck.
- 评估了视网膜和胆道血管的发现,包括毛细血管的非 perfusion 和密度.
主要成果:
- 通过ICGA识别了超反射点 (36.4%) 和类似血管瘤的病变 (8.0%).
- 在表面毛细管 (47.7%) 和深层毛细管 (23.9%) 中观察到毛细管不 perfusion.
- 发现毛细管密度下降与非输液相关,毛细管密度和壁对光线比率之间存在负相关性.
结论:
- 后急性COVID-19与显著的视网膜和胆道血管异常有关.
- 这些患者的眼部病理与毛细血管密度下降有关.
- 微血管干扰,而不是葡萄糖异常,似乎是这些眼睛损伤的主要原因.
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