肌体学和代谢学在阴风相关的男性不孕症:推进精确诊断和治疗
Aris Kaltsas1, Athanasios Zikopoulos2, Eleftheria Markou3
1Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Journal of clinical medicine
|December 17, 2024
概括
蛋白质组学和代谢组学为诊断由静脉引起的男性不孕症提供了新的方法. 这些先进的技术可以识别分子变化,为治疗瘤不孕症的个性化治疗铺平了道路.
科学领域:
- 生殖医学 生殖医学
- 生物化学 生物化学
- 基因组学和蛋白质组学
背景情况:
- 静脉是男性不育的主要原因,但目前的诊断往往错过了微妙的分子损伤.
- 这限制了针对受影响个体开发有针对性的治疗方法.
研究的目的:
- 审查蛋白质学和代谢学方面的进展,以诊断与静脉相关的男性不孕症.
- 探索这些"omics"技术在指导个性化治疗策略方面的潜力.
主要方法:
- 在PubMed,Scopus和Web of Science的综合文献搜索到2024年10月.
- 选择和批判性分析应用蛋白质组和代谢组分析来研究静脉不孕症的研究.
主要成果:
- 蛋白质组学确定了与氧化应激,线粒体功能障碍和亡相关的精子和精液等离子体中的改变蛋白质.
- 代谢学揭示了与精子功能受损相关的精子血代谢物特异性变化 (例如, lysine, valine, fructose 的减少).
- 综合的奥米克数据为瘤不孕症提供了分子指纹,有助于生物标志物发现.
结论:
- 蛋白质组学和代谢组学增强了对静脉瘤不孕症分子基础的理解.
- 这些"omics"技术有望提高诊断准确度,并为男性不孕症提供个性化治疗.
- 需要进一步的临床试验来验证生物标志物的常规实践.
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