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在治疗急性严重性结肠炎的近期进展
Elaine Ong Ming San1, Kassem Sharif1,2,3, Konstantina Rosiou1
1Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, St James University Hospital, Bexley Wing, Beckett Street, Leeds LS9 7TF, UK.
急性严重性结肠炎需要及时治疗. 虽然infliximab和cyclosporine是有效的救援疗法,但正在探索像Janus激酶抑制剂这样的新药,以避免手术.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床药理学 临床药理学
背景情况:
- 急性严重性结肠炎是一种医疗紧急情况,需要静脉注射类固醇的住院治疗.
- 很大一部分患者 (大约三分之一) 对类固醇反应不足,需要医疗救援治疗.
研究的目的:
- 审查目前已确立的急性严重性结肠炎治疗途径.
- 报告关于管理这种疾病的最新发展和不断发展的概念.
主要方法:
- 对急性严重性结肠炎的既定治疗方案的审查.
- 分析新兴的治疗策略,包括救援剂和新药类.
主要成果:
- 因弗利西马布和环素是同样有效的救生剂,因实用原因,因弗利西马布往往是首选的.
- 环素的使用正在增加,特别是在以前接触过因弗利克西马布的患者中.
- 简氏激酶抑制剂显示出潜力,但需要进一步的随机试验.
- 强化施用infliximab的效果不一,但可能有利于特定的患者亚组.
结论:
- 已建立的治疗途径包括类固醇和救援疗法,如因弗利西马布或环素.
- 包括Janus激酶抑制剂在内的新型药物正在研究中,以改善结果并可能避免胆管切除.
- 进一步的研究对于确定新疗法在治疗急性严重性结肠炎中的作用至关重要.
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