新生儿血清肌素动态的预后价值-一项回顾性队列研究
Flavia Chisavu1,2, Lazar Chisavu1,3, Adalbert Schiller1,3
1Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Journal of clinical medicine
|December 17, 2024
概括
监测新生儿的血清肌素趋势至关重要. 生命第一个星期的上升趋势显著增加了新生儿急性损伤 (nAKI) 和死亡率的风险.
科学领域:
- 新生儿医学 新生儿医学
- 儿科病学 儿科病学
- 关键的护理关键的护理
背景情况:
- 新生儿急性损伤 (nAKI) 很普遍,导致死亡率增加和住院时间延长.
- 有限的研究存在于与出生时血清肌素动态相关的nAKI结果.
- 这项研究通过检查新生儿早期血清肌素趋势来弥补这一差距.
研究的目的:
- 调查血清肌素在生命的第一个星期的趋势和新生儿的结果之间的关联.
- 评估升与降肌素趋势对死亡率,住院和慢性病进展的影响.
- 在新生儿中识别nAKI风险的早期指标.
主要方法:
- 一项对1106名新生儿 (2014-2022) 的观察性,回顾性,单中心研究.
- 血清肌素水平记录在第1天和第2至7天之间.
- 分析的结果包括死亡率,住院时间和进展到慢性病.
主要成果:
- 23.4%的新生儿表现出血清肌素上升的趋势,与较差的初始临床标志物相关.
- 升的肌素趋势显著增加了nAKI的风险 (12.93x在前7天,4.07x整体).
- 上升趋势独立地增加了死亡风险 (整体1.92倍,非AKI亚组4.65倍) 和慢性病风险 (原始8.74倍).
结论:
- 新生儿是高风险群体,需要保持警的监测,无论肌素的趋势如何.
- 第一周血清肌素上升趋势是增加nAKI和死亡风险的关键指标.
- nAKI是新生儿慢性病发展的独立风险因素.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
53
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
53
01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
71
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
71
01:23Renal Clearance
718
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
718