严重的爱斯坦-巴尔病毒脑炎与外围神经损伤:一个病例报告.
Aidi Luo1, Chang Li, Jing Zhao
1Department of Neurology, The Second People's Hospital of Guiyang (Jinyang Hospital), Guiyang, Guizhou, China.
Medicine
|December 17, 2024
概括
爱斯坦-巴尔病毒 (EBV) 脑炎很少见,但可能导致严重的神经和外围神经损伤. 早期诊断使用大脑脊髓液下一代代基因组测序 (NGS) 对于及时治疗和改善结果至关重要.
科学领域:
- 神经病毒学 神经病毒学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 爱普斯坦-巴尔病毒 (EBV) 是一种常见的B型淋巴热性疹病毒,通常会导致无症状的感染.
- 像EBV脑炎这样的严重表现很少见,外围神经损伤更不常见.
研究的目的:
- 报告一种罕见的严重的爱斯坦-巴尔病毒脑炎病例,并由外围神经损伤复杂化.
- 突出在脑脊液中基因组下一代测序 (NGS) 的诊断实用性,用于在复杂的神经病例中识别EBV.
主要方法:
- 一个49岁的女性呈现出发烧,手部软弱和言语不清的案例研究.
- 诊断程序包括电肌图,MRI和脑脊液的下一代代基因组测序 (NGS).
- 治疗包括抗病毒和激素治疗.
主要成果:
- 患者表现出严重的中枢神经损伤和多个脑损伤与勒普托门关节增强.
- 在脑脊液中通过NGS检测出EBV.
- 尽管进行了干预,但患者经历了神经系统的恶化,心脏病发作,多器官衰竭,并最终死亡.
结论:
- 大脑脊髓液 (NGS) 是一种有价值的工具,用于在患有神经症状的患者中早期和准确诊断EBV脑炎.
- 迅速诊断和治疗中枢神经系统感染对于降低死亡率和改善患者预后至关重要.
相关概念视频
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...


