在急性缺血性中风患者中,miRNA与心脏病发作体积的相关性:系统性审查
Yanmeng Yang1, Guangming Wang2, Yanlong Tang1
1Radiology Department of the First Affiliated Hosptial of Dali University, Dali, Yunnan, China.
Medicine
|December 17, 2024
概括
微RNAs (miRNAs) 显示为急性缺血性中风 (AIS) 的生物标志物具有前途. 某些miRNA与心脏病发作量相关,有助于AIS患者的预后和临床判断.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 神经学 神经学
背景情况:
- 诊断急性缺血性中风 (AIS) 需要可靠的生物标志物.
- 微RNA (miRNA) 是稳定的,在体液中发现的组织特异性RNA分子.
- miRNAs显示出作为组织损伤的敏感指标的潜力.
研究的目的:
- 在AIS患者中系统地审查miRNAs和心脏病发作体积之间的相关性.
- 建立预测中风发作和改善临床预后的基础.
主要方法:
- 在2023年7月1日之前对英语和中文文学进行系统审查.
- 搜索的数据库:PubMed,科克兰图书馆,CNKI,VIP,万芳.
- 使用12项和Cochrane风险偏差工具评估研究质量.
主要成果:
- 包括17项研究,包括1443例AIS病例和18个miRNA指标.
- 九个miRNA指标显示出与心脏病发作体积的积极关联.
- 确定的特定的miRNA包括miR-155,miR-146b,miR-181c,miR-182,miR-34a,miR-92a,miR-122-5p,miR-451a和miR-409-3P. 这三种miRRNA的特征包括:
结论:
- miRNAs可以作为AIS的有效生物标志物.
- miRNA水平反映了AIS患者的神经缺陷严重程度.
- 这为AIS的临床预后评估提供了基础.
相关概念视频
01:15Ischemic Stroke l: Introduction
53
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
53
01:15Ischemic Stroke ll: Pathophysiology
68
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
68