在肝硬化患者中,自发性细菌周周炎的短期和长期死亡率
Tsung-Hsing Hung1,2, Chih-Ying Wang3, Chih-Chun Tsai4
1Division of Gastroenterology, Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Medicine
|December 17, 2024
概括
肝硬化患者的自发细菌性腹膜炎 (SBP) 的30天死亡率为10.8%,但长期存活率仍然很差. 败血症和脏问题显著恶化了这些患者的短期预后.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 自发性细菌性腹膜炎 (SBP) 是肝硬化患者的一种严重并发症.
- 了解SBP死亡率趋势对于患者管理和预后至关重要.
研究的目的:
- 重新评估与SBP相关的短期和长期死亡率.
- 确定影响SBP后生存的显著预后因素.
主要方法:
- 使用台湾国家医疗保险数据库进行的回顾性队列研究.
- 包括在2014-2015年期间在SBP后出院的925名肝硬化患者.
- 长达3年的随访以追踪结果和考克斯回归分析.
主要成果:
- 30天,90天,1年和3年的总死亡率分别为10.8%,23.0%,44.0%和60.9%.
- 确定了关键的短期预后因素:晚年 (HR=1.03),并发性败血症 (HR=2.73),功能障碍 (HR=3.28).
- 尽管30天死亡率约为10%,但长期生存仍然是一个重大挑战.
结论:
- SBP继续与肝硬化患者的高短期和长期死亡率有关.
- 功能障碍和并发性败血症是短期预后不良的关键指标.
- 进一步研究改善SBP患者的长期结果是有必要的.
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