预先存在痴呆症患者的长期COVID-19结果
Roham Hadidchi1, Rachel Pakan1, Tharun Alamuri2
1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Journal of Alzheimer's disease : JAD
|December 17, 2024
概括
COVID-19显著增加了痴呆症患者的死亡率和不良健康结果. 这凸显了对这种脆弱人群感染后加强监测和量身定制的管理策略的需要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
背景情况:
- COVID-19对痴呆症患者的长期影响尚不清楚.
- 之前的研究表明神经退行性疾病中潜在的急性并发症.
研究的目的:
- 为了调查COVID-19感染后痴呆症患者的健康结果.
- 在这个人群中确定与COVID-19相关的特定风险和不良事件.
主要方法:
- 从2016年1月到2023年7月,对9806名痴呆症患者进行了回顾性研究.
- 患有和没有COVID-19 (SARS-CoV-2 PCR阳性) 的痴呆症患者之间的结果比较.
- 分析包括全因死亡率,主要不良心血管事件 (MACE) 和新发的神经和呼吸系统症状,调整为共变量.
主要成果:
- 与非COVID对照组相比,患有痴呆症的COVID-19幸存者面临65%的死亡风险增加.
- 在COVID-19和MACE风险增加,新发性消化不良,呼吸不良,疲劳,睡眠障碍,精神状态变化和跌倒之间发现了显著的关联.
- 患有COVID-19的痴呆症患者更年轻,更男性,并患有更多的并发症.
结论:
- COVID-19 构成重大威胁,在痴呆症患者中增加死亡率和不良健康风险.
- 调查结果强调,在COVID-19之后,对于痴呆症患者来说,急需加强随访和专门的管理计划.
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