相关实验视频

Updated: Jun 4, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

在酒精使用障碍中减少大脑网络分离:与神经认知相关联

Xinying Wang^1,2, Peter Manza³, Xinyi Li¹

¹Center for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Addiction biology

|December 17, 2024

概括

患有酒精使用障碍 (AUD) 的个人表现出大脑网络分离减少和空间工作记忆受损,这表明大脑过早衰老. 这与健康对照 (HCs) 相反,并突出了AUD的潜在神经生物学影响.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
成研究研究成研究

背景情况:

酒精使用障碍 (AUD) 与早期大脑衰老和认知缺陷有关.
减少大脑网络分离与与年龄相关的认知衰退有关.
假设:AUD患者的脑网络分离率低于健康对照组 (HCs).

研究的目的:

为了研究AUD患者和HC患者之间大脑网络分离的差异.
在AUD和HC中检查大脑网络分离,年龄和空间工作记忆之间的关系.

主要方法:

休息状态功能性MRI (rs-fMRI) 用于评估大脑网络分离.
参与者包括30名AUD患者和61名HC患者.
在传感运动和协会网络中分析了分离.

主要成果:

与HC相比,AUD患者在感觉运动和关联网络中显示出明显较低的分离率.
在空间工作记忆任务中,AUD患者的表现更差.
在HC中,网络隔离与年龄负相关,与空间工作记忆正相关.

结论:

在AUD中减少大脑网络分离可能是认知障碍的基础.
这些发现支持了AUD患者早期大脑衰老的假设.
大脑网络组织在AUD中发生变化,影响认知功能.

关键词:

酒精使用障碍饮酒障碍认知认知认知分离隔离的分离.

更多相关视频

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

相关概念视频

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...