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在纳米酶中工程双重活性位点和缺陷结构,以重编程骨微环境,用于骨质放射性死治疗

Zheng Cheng¹, Yuchen Wang¹, Haobo Lin¹

¹Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|December 17, 2024

概括

铁氧化瓦纳 (Fe-VOx) 纳米酶清除反应性氧和物种 (RONS) 以治疗下巴骨质放射性死 (ORNJ). 这些纳米酶恢复线粒体功能,增强线粒体和抑制感染,提供了一种新的治疗策略.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

骨放射性死 (ORNJ) 影响4-8%的头癌患者进行放射治疗后.
辐射诱导的组织损伤与反应性氧和物种 (RONS) 的过度生产有关.

研究的目的:

为ORNJ治疗开发具有多酶活性的Fe-doped VOx (Fe-VOx) 纳米酶.
研究Fe-VOx纳米酶在清除RONS,恢复线粒体功能和抑制感染方面的有效性.

主要方法:

在VOx纳米酶的Fe兴奋剂中产生Fe替代和氧空缺 (OVs) 等缺陷.
评价Fe-VOx纳米酶的催化酶 (CAT),超氧化脱氧化酶 (SOD) 和谷氨过氧化酶 (GPx) 的酶模仿活动.
评估Fe-VOx纳米酶重新编程骨微环境的能力,恢复线粒体功能障碍,并增强线粒细胞衰变.
在光热疗法中利用表面等离子体共振 (SPR) 效应来抑制下感染.

主要成果:

铁注显著增强了VOx纳米酶的多酶模仿活动.
Fe-VOx纳米酶有效地清除了RONS,恢复了线粒体功能,并促进了线粒体.
Fe-VOx纳米酶的表面等离子体共振 (SPR) 效应显示出强大的光热抗菌活性.

结论:

Fe-VOx纳米酶具有多酶活性,可以有效地清除RONS和激活线粒细胞.
Fe-VOx纳米酶显示出作为光热剂的潜力,可以抑制部感染.
这项研究将Fe-VOx纳米酶作为治疗ORNJ的有希望的治疗候选者.

关键词:

具有类似酶的性能.线粒细胞衰变 (mitophagy) 是一种神经衰变.纳米酶是一种纳米酶.骨的骨质放射性 necrosis 的下巴.有活性氧和物种的反应性氧和物种.

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