相关实验视频

Updated: Jun 4, 2025

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

在有条件的Nlrc5-缺乏的小鼠中,BAFF阻塞减弱了B细胞MALT的形成,这些小鼠感染了Helicobacter felis

Dongmei Tong^1,2, Yuqi He¹, Shambel Araya Haile^1,2

¹Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

European journal of immunology

|December 17, 2024

概括

球菌感染通过增加B细胞激活因子 (BAFF) 来驱动胃B细胞淋巴瘤. 阻断BAFF信号显著降低了淋巴瘤的发展,这表明BAFF抑制是一种潜在的治疗方法.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
在瘤学瘤学.

背景情况:

球菌感染是胃粘膜相关淋巴组织 (MALT) 淋巴瘤的主要原因.
B细胞激活因子 (BAFF) 对B细胞增殖至关重要,并与各种B细胞疾病有关.

研究的目的:

为了研究BAFF在Helicobacter诱导的胃MALT淋巴瘤中的作用,使用鼠标模型对NOD类受体家族CARD域含5 (Nlrc5) 的条件淘汰进行了研究.

主要方法:

在NLRC5条件淘汰赛小鼠中利用了Helicobacter felis感染.
在胃炎发作之前和之后给药的BAFF信号封锁.
分析了胃免疫细胞群和巨细胞中的BAFF转录变异.

主要成果:

在NLrc5缺乏的小鼠中,Helicobacter felis感染显著增加了胃BAFF的产生.
BAFF封锁显著减少了MALT发育,胃B细胞毛囊和腺腺增生.
BAFF抑制改变了胃免疫细胞格局,并将TNFSF13B (BAFF) -206确定为一个关键的上调调节的转录.

结论:

NLRC5-BAFF信号轴与Helicobacter诱导的胃B细胞MALT淋巴瘤有关.
准BAFF信号传输为这种恶性瘤提供了一个有前途的治疗策略.

关键词:

B细胞是B细胞的组成部分.B细胞激活因子 (BAFF)在Helicobacter Pylori的研究中,粘膜相关淋巴组织 (MALT) 淋巴瘤非霍奇金淋巴瘤的非霍奇金淋巴瘤.

更多相关视频

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

相关概念视频

B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...