在无意的双剂量布洛皮安暴露中,剂量间的时间是否会影响副作用的发生率? 一个回顾性队列研究
Michael Keenan1,2, Precious Alabi3, Ahmed Alsakha4,5
1Department of Emergency Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Clinical toxicology (Philadelphia, Pa.)
|December 17, 2024
概括
在无意中加倍剂量后,第二剂布洛普的时间似乎不会影响诸如发作或心动减速等不良反应. 这一发现表明,剂量计时不是风险分层的可靠因素,布普罗过量患者.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床毒理学 临床毒理学
- 患者安全 患者安全
背景情况:
- 涉及布洛普的无意治疗错误很常见.
- 双剂量暴露中剂量间隔对不良事件的影响尚未得到充分证实.
研究的目的:
- 为了研究第二剂量时间间隔与意外摄入双剂量布洛的不良影响之间的关系.
- 为了确定剂量计时是否可以用于布洛普过量剂的风险分层.
主要方法:
- 一项回顾性队列研究分析了来自区域中毒中心 (2018-2022) 的数据.
- 包括的患者有无意的,单一物质,双剂量布洛暴露.
- 在用剂间隔<720分钟和≥720分钟的组之间比较了不良反应.
主要成果:
- 在294名符合标准的患者中,大多数患者使用延长释放布洛 (69.0%).
- 在剂量间隔组之间没有观察到发作 (2.7%对比7.7%),心动减速 (27.0%对比30.8%) 或高血压 (18.9%对比38.5%) 的显著差异.
- 总体上,不良事件 (48.6%与61.5%) 根据双剂量之间的时间没有显著差异.
结论:
- 在延长释放布洛双剂量暴露中,第二剂量的时间似乎不是患者风险分层的可靠因素.
- 需要进行更大规模的前性研究,以进一步阐明这些摄入物的管理.
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