相关实验视频
Updated: Jun 4, 2025

07:33
Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
23.1K
免疫疗法使用Pullulan结合的Derf 2过敏原在犬类亚托邦性皮肤炎:一种抗炎剂节约的方法
Masahiko Nagata1, Jin Kozakai2, Aya Yoshida3
1ASC, Chofu, Tokyo, Japan.
Veterinary dermatology
|December 17, 2024
概括
普卢兰结合复合Derf 2 (rDf2-P) 免疫疗法显著减少了一年多的阿托皮性皮肤炎的狗的抗炎药物使用. 这种治疗显示出作为有效的主动治疗犬皮炎 (cAD) 的承诺.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 免疫治疗是一种免疫疗法.
- 狗类无氧皮肤炎 (cAD)
背景情况:
- 过敏原免疫疗法是一种已被认可的病因治疗犬类亚托皮炎 (cAD) 的方法.
- 需要有效的,长期的cAD管理策略对于改善犬类生活质量至关重要.
研究的目的:
- 在1年的时间内评估Pullulan结合复合Derf2 (rDf2-P) 免疫疗法对抗炎症剂的节约潜力.
- 评估对接受rDf2-P.的cAD犬的临床疗效和对药物需求的影响.
主要方法:
- 21只被诊断患有cAD的私人拥有的狗被纳入.
- 狗接受了1年的rDf2-P免疫疗法,每月药物评分 (MS) 和临床评估 (CADESI-04,湿疹,).
- 血清胸腺和激活调节的化学激素 (TARC) /C-C动机化学激素连接物-17 (CCL17) 水平进行了监测.
主要成果:
- 在整个1年的治疗期间,观察到平均药物评分的显著降低.
- 大多数狗在4.5个月和13.5个月后观察到优秀或良好的药物缓解效果.
- 较低的CADESI-04分数与明显较低的血清TARC/CCL17度相关.
结论:
- rDf2-P免疫疗法有效地减少了患有cAD的狗的抗炎药物的需要.
- 这种免疫疗法显示出作为一种主动和有效的治疗选择来治疗犬类亚托皮炎的潜力.
相关概念视频
Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
141
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
141
Inflammatory Bowel Disease IV: Pharmacological Management
111
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
111
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
95
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
95

