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调查哈西莫托甲状腺炎和乳头甲状腺癌之间的关联
Adriana I Báez Berríos1, Mathilda Monaghan1, Margaret Brandwein-Weber2
1Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Head & neck
|December 17, 2024
概括
哈西莫托甲状腺炎 (HT) 不会影响在乳头甲状腺癌 (PTC) 中的侵袭性淋巴结 (ALN) 状态. 这项研究发现,在有HT和没有HT的PTC患者之间,ALN状态没有显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 哈西莫托甲状腺炎 (HT) 对乳头甲状腺癌 (PTC) 侵袭性淋巴结 (ALN) 状态的影响尚不清楚.
- 了解这种关系对于预测PTC进展和患者结果至关重要.
研究的目的:
- 为了研究同时发生的哈西莫托甲状腺炎和在乳头甲状腺癌中具有攻击性的淋巴结状况之间的关联.
- 为了比较具有和没有HT的PTC患者的临床病理特征和ALN状态.
主要方法:
- 对533名PTC患者的回顾性分析,比较那些有 (PTC+HT) 和没有HT的患者.
- 使用单变量和多变量分析来评估PTC攻击性标志物.
- ALN的分类包括>5个正节点,≥1个节点>3cm,和/或≥4个节点与 extranodal扩展.
主要成果:
- 在533名PTC患者中,19.1%患有并发性HT. PTC+HT患者更常见的是女性,年轻,非吸烟者,并且有更多的pN0阶段瘤.
- PTC+HT与pN1阶段和淋巴细胞入侵的几率较低有关.
- 在ALN状态,pT阶段,入侵, extranodal扩展,边缘或焦点之间没有观察到显著的差异.
结论:
- 侵袭性淋巴结状况在患有和没有哈西莫托甲状腺炎的乳头甲状腺癌患者之间没有显著差异.
- 在PTC中,HT的存在似乎不会影响淋巴结转移的可能性.
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