肠粘膜干扰的病理学;从青春晚期到八代人的肌肉损失和身体依赖的影响
Rizwan Qaisar1,2,3, Asima Karim1, M Shahid Iqbal4
1Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
International journal of general medicine
|December 17, 2024
概括
肠道透率的增加,如血佐努林所示,与成年人肌肉损失和身体衰退有关. 这种情况从中年开始发生,导致软弱和依赖.
科学领域:
- 老年学是一门学科.
- 生理学 生理学 生理学
- 胃肠病学 胃肠病学
背景情况:
- 肠道透性的病理性增加有助于通过全身炎症和氧化应激导致肌肉损失和身体衰退.
- 现有的研究主要集中在老年人身上,在不同年龄组之间留下了解的差距.
- 肠道透性对整个寿命内的肌肉健康和身体功能的作用需要进一步研究.
研究的目的:
- 调查肠道透性与肌肉损失和身体衰退之间的关系,跨越广泛的年龄范围.
- 评价血佐努林作为肠道透性的标志物,与肌肉健康和步行速度相关.
- 探索肠道透性标记物与炎症和氧化应激指标之间的相关性.
主要方法:
- 一项横截面的观察性研究,涉及18~90岁的健康男性,分为年轻人,中年人和老年人.
- 通过ELISA测试进行的测量包括血佐努林,C反应蛋白 (CRP) 和8-异质.
- 肌肉健康的评估包括手握强度 (HGS) 和骨肌肉质量指数 (SMI),以及步行速度测量.
主要成果:
- 随着年龄的增长,血中佐努林水平增加,而HGS和步行速度在不同年龄组逐渐下降.
- 与年轻和中年男性相比,年长的成年人表现出较低的SMI.
- 血佐努林与HGS和步行速度有显著的负相关性,与CRP和8-异素有积极相关性,特别是在中年和老年人中.
结论:
- 肠道透率升高,由从中年开始的血阳素升高表明,与肌肉衰弱和身体衰退有关.
- 这些发现强调了肠道透性在理解和管理中年和老年人身体依赖性的临床相关性.
- 血阳素作为肌肉力量和步行速度降低的潜在诊断标志物.
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