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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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优化挤出工艺,并理解使用线性UV-Vis光谱和QbD原理在伊特拉科纳无形固体分散中的构造变化

Hetvi Triboandas1, Mariana Bezerra2, Juan Almeida3

  • 1Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.

International journal of pharmaceutics: X
|December 17, 2024
PubMed
概括

这项研究优化了使用热挤出和实时UV-Vis监测进行伊特拉科纳 (ITZ) 无形固体分散 (ASD) 制造. 优化条件确保产品质量的一致性,并证明UV-Vis.

关键词:
形态固体分散 (ASD) 是一种无形固体分散.密度函数理论 (DFT) 是一种密度函数理论.实验设计 (DOE) 实验的设计热挤出 (HME) 是一种热挤出技术.伊特拉科纳 (ITZ) 是一种设计质量 (QbD),直线UVV光谱学.

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