麻醉诱导的儿童群体发育神经毒性
Fihr Chaudhary1, Devendra K Agrawal1
1Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Journal of surgery and research
|December 17, 2024
概括
麻醉剂可能会对儿童的大脑发育产生负面影响,导致长期的神经认知问题. 有证据表明,早期麻醉暴露可能会造成伤害,因此在儿科护理中需要仔细考虑.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 神经科学是一个神经科学.
- 发育毒理学 发展毒理学
背景情况:
- 麻醉剂和镇静剂可能会给儿童带来长期神经认知后果的风险.
- 动物研究表明,早期麻醉暴露可能导致神经发育障碍和脑细胞死亡.
- 临床观察和监管机构的关注凸显了对麻醉对儿科神经发育的影响的担忧.
研究的目的:
- 批判性地审查关于儿童麻醉诱导的神经毒性的临床研究结果.
- 系统地分析有关早期麻醉剂暴露的神经和认知影响的证据.
- 讨论小儿麻醉神经毒性的潜在机制,病理生理学和伦理考虑.
主要方法:
- 对现有的临床发现和流行病学调查进行系统审查和批判性分析.
- 评估结果指标,如神经心理测试,教育干预和学术表现.
- 讨论潜在的机制,包括线粒体,内分泌网膜和 lysosomal 途径.
主要成果:
- 多项人类流行病学研究表明,在早期暴露于麻醉剂后,神经障碍和认知能力下降.
- 经过验证的神经心理测试和学术结果支持全身麻醉与神经发育不良影响之间的关联.
- 有证据表明,对儿科患者麻醉诱导的神经毒性的担忧并不夸大.
结论:
- 手术麻醉对儿科神经毒性的潜在不良影响是显著的,需要进一步调查.
- 虽然需要进行详细的临床研究,但目前的证据支持早期麻醉暴露与神经认知缺陷之间的联系.
- 了解病理生理学和伦理含义对于安全的儿科麻醉实践至关重要.
关键词:
麻醉诱导的发育神经毒性亡途径 (apoptotic pathways) 是指发生亡的途径.遗传性心脏病是一种先天性心脏病.细胞内膜网膜是什么 细胞内膜网膜它是一种GABA激动剂.氧气过低是因为缺氧.Lysosomes 是一个溶解体.线粒体功能障碍 线粒体功能障碍这是一种NMDA抗剂.神经亡 (Neuroapoptosis) 这是一种神经亡.神经认知障碍是一种神经认知障碍.神经发育结果的神经发育结果神经新生是神经发生的过程.神经毒性 神经毒性儿科麻醉 儿科麻醉这就是Synaptogenesis.更多相关视频
相关概念视频
01:12Local Anesthetics: Adverse Effects
386
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
386
01:24Parenteral Anesthetics: Overview
97
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
97
01:21Factors Affecting Drug Response: Overview
1.8K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.8K
01:20Inhalational Anesthetics: Overview
178
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
178
01:22Stages of General Anesthesia
364
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
364