ALDH1L2通过TAM极化驱动HCC的进展
Jiajun Li1, Chi Zhang1, Qingqing Zhou1
1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
JHEP reports : innovation in hepatology
|December 17, 2024
概括
脱酶1家族成员L2 (ALDH1L2) 通过激活NRF2/IL-6/STAT3信号,促进肝细胞癌 (HCC) 的进展和转移. 向ALDH1L2可能会提高HCC治疗中索拉芬尼的疗效.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 代谢途径 代谢途径
背景情况:
- 不调节的单碳代谢与线粒体功能障碍和癌症有关.
- 脱酶1家族成员L2 (ALDH1L2) 与瘤进展有关,但其在肝细胞癌 (HCC) 中的作用尚不清楚.
研究的目的:
- 研究ALDH1L2在HCC进展中的作用和分子机制.
- 探索ALDH1L2作为HCC的潜在治疗点.
主要方法:
- 在HCK组织和细胞系中评估ALDH1L2表达,使用免疫组织化学,西部涂抹和免疫光.
- 进行了体外和体内测试,以确定ALDH1L2在HCC中的功能作用和调节途径.
主要成果:
- ALDH1L2上调与HCC预后不佳相关 (HR=1.923,p=0.04).
- ALDH1L2通过NRF2/IL-6/STAT3信号激活促进HCC细胞的增殖和转移.
- ALDH1L2通过NRF2稳定增强线粒体呼吸,ATP生产和ROS诱导的损伤保护,形成一个积极的反循环.
- ALDH1L2与瘤相关的巨细胞相互作用,促进HCC的进展.
- 通过ALDH1L2 Knockdown,使HCC细胞对索拉费尼布产生敏感.
结论:
- ALDH1L2是HCC进展的关键驱动因素,通过Jak2/STAT3信号与瘤相关的巨细胞相互作用.
- ALDH1L2 作为 HCC 的预后标志物和潜在的治疗点.
- 向ALDH1L2可能会提高索拉芬尼在HCC治疗中的疗效.
更多相关视频
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.1K
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.8K
相关概念视频
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
02:23Abnormal Proliferation
4.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.4K