肠道微生物群变化与老年人虚弱相关:观察性研究的系统综述
Na-Na Wen1,2, Li-Wei Sun1, Qian Geng1
1College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
World journal of clinical cases
|December 17, 2024
概括
肠道微生物组的变化与老年人的脆弱性有关. 脆弱的个体表现出有益细菌减少和潜在有害物种增加,表明肠道失调. 需要进一步的研究.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 虚弱是一种与衰老相关的综合征,增加了对不良结果的脆弱性.
- 人们越来越认识到肠道微生物群在脆弱病理生理学中的作用.
- 有限的直接证据存在于脆弱的老年人肠道微生物组的改变.
研究的目的:
- 在脆弱的老年人中调查肠道失调.
- 系统地审查肠道微生物群与脆弱性之间的联系.
主要方法:
- 11项观察性研究的系统综述.
- 在七个电子数据库中搜索了2023年10月31日之前发表的文章.
- 使用纽卡斯尔-太华尺度和AHRQ标准评估研究质量.
主要成果:
- 脆弱的老年人表现出改变了肠道微生物群的多样性和组成.
- 在脆弱个体中观察到α多样性的显著减少和β多样性的增加.
- 在脆弱的成年人中丰富了Actinobacteria,Proteobacteria,Verrucomicrobia,Synergistetes;耗尽了Firmicutes,Fusobacteria.
- 减少了有益的属 (Prevotella,Faecalibacterium,Roseburia) 的丰富性,并增加了病原性物种.
结论:
- 肠道微生物群的改变与老年人的虚弱有关.
- 脆弱的特点是有益的肠道微生物物种减少和致病性肠道微生物物种增加.
- 需要进一步的研究来证实这些发现并阐明机制.
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