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高亲和度的仿制抗原受体信号诱导人体调节性T细胞中的炎症程序

Russell W Cochrane1,2,3, Rob A Robino1,2,3, Bryan Granger4

  • 1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

Molecular therapy. Methods & clinical development
|December 17, 2024
PubMed
概括

调节性T细胞 (Tregs) 中的化学抗原受体 (CAR) 激活可以增强它们的细胞毒性,但降低它们的抑制功能. 定制CAR设计对于有效的基于Treg的疗法至关重要.

关键词:
这就是T细胞信号传递.细胞身份是细胞的身份.仿制性抗原受体的仿制性抗原受体人类免疫学人类免疫学免疫细胞疗法是一种免疫细胞疗法.免疫耐受性 免疫耐受性炎症性细胞因子是炎症性细胞因子.接收器亲缘关系 接收器亲缘关系监管性T细胞监管性T细胞合成免疫学 合成免疫学

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