炎症负担指数:在腹腔透析患者中,系统性炎症的优异预后生物标志物
Jiexin Chen1, Ruiying Tang1, Na Tian2
1Department of Nephrology, Jiangmen Central Hospital, Jiangmen, People's Republic of China.
Journal of inflammation research
|December 17, 2024
概括
基于炎症的指数 (IBI) 是围透析 (PD) 患者生存的优越预测指标. 较高的IBI独立地预测了PD患者因各种原因和心血管死亡率的风险较高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 生物标志物 生物标志物
背景情况:
- 常规血液检查中的系统性炎症生物标志物与腹腔透析 (PD) 患者的预后有关.
- 之前比较这些生物标志物在PD患者的预测功效的研究是有限的,并产生不一致的结果.
研究的目的:
- 评估PD患者各种系统性炎症生物标志物的预后价值.
- 为了确定最佳的生物标志物来预测PD患者的预后.
主要方法:
- 一项对中国3225名PD患者进行的纵向研究.
- 使用C统计评估的预测准确性.
- 通过多变量考克斯比例危险回归分析识别的独立预后生物标志物.
主要成果:
- 在46个月的随访期间,829名 (25.7%) 患者死亡,458名 (55.3%) 患有心血管疾病 (CVD).
- 基于炎症的指数 (IBI) 显示了最高的C统计数据 (所有原因的0.619,心血管疾病死亡率的0.621).
- 较高的IBI独立预测了所有原因和心血管疾病死亡率的更高风险;最佳值为50.0.
结论:
- IBI是PD患者生存的优越预后指标,并且广泛适用.
- 升高的IBI是PD患者全因和心血管疾病死亡率的独立风险因素.
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