罗莫苏祖马布治疗心血管结果-现实世界数据分析分析
Anat Tsur1,2, Avivit Cahn2,3, Ludmila Levy1
1Department of Endocrinology and Metabolism, Clalit Health Services, Jerusalem 9310609, Israel.
在绝经后的女性中,针对骨质疏松症的罗莫苏祖马布治疗显示出主要心血管不良事件 (MACE) 的持续率. 这项现实研究表明,罗莫苏祖马布与心血管风险的增加无关,这挑战了以前的担忧.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 骨质疏松症的治疗通常涉及具有潜在副作用的药物.
- 罗莫苏祖马布是一种有效的骨质疏松症治疗方法,但其心血管安全性仍然令人担忧.
- 在临床试验之外评估药物安全性时,现实世界的数据至关重要.
研究的目的:
- 为了评估romosozumab在现实世界队列中的心血管安全性.
- 评估在罗莫苏祖马布治疗期间和之后发生的重大心血管不良事件 (MACE) 的发生率.
- 为了将心血管事件率与以前的报告进行比较.
主要方法:
- 在接受Romosozumab治疗的绝经后妇女进行了回顾性队列研究.
- 纳入标准:在2020年1月至2023年6月期间开始使用罗莫祖马布.
- 对MACE发生的随访,并对随时间的事件率进行分析.
主要成果:
- 847名女性接受了平均729天的随访.
- MACE 的总发病率为每 1000 人/年 24.0 人/年.
- 在治疗期间,MACE的发病率保持一致,没有统计学上显著的增加,即使是在先前患有心血管疾病或糖尿病的患者中.
结论:
- 对于绝经后妇女的重大心血管不良事件,罗莫苏祖马布治疗似乎是安全的.
- 现实世界的数据支持罗莫苏祖马布的心血管安全概况.
- 这些发现挑战了之前对治疗第一年内心血管事件增加的担忧.
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