乳腺生物标志物在初级转移和远程转移之间演变:发生率和意义
Maha Khedr1, Shipra Gandhi2, Arya Mariam Roy2
1Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Histopathology
|December 17, 2024
概括
将转移性乳腺癌 (BC) 分类为五个配置文件,包括人体表皮生长因子2 (HER2) 低,与三个配置文件相比,更清楚地了解治疗演变. 这种详细的分类会影响生存结果,特别是在HR-负/HER2-零病例中.
科学领域:
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
- 癌症基因组学 癌症基因组学
背景情况:
- 乳腺癌 (BC) 的分类会影响治疗策略.
- 人类表皮生长因子2 (HER2) 低状态在BC进化中的作用越来越被认可.
研究的目的:
- 用三种和五种临床形状来评估BC演变.
- 将HER2-低状态纳入生物标志物配置文件,以便进行更细致的分类.
主要方法:
- 对161例转移性BC病例的回顾性分析,记录了荷尔蒙受体 (HR) 和HER2状态.
- 将其分为三种 (HR+/HER2-, HER2+,TNBC) 和五种 (包括HER2-zero和HER2-low) 的分类.
主要成果:
- 进化发生在22.4%的三种情况和36.6%的五种情况.
- HR-负/HER2-零在五个配置分析中显示了最差的整体存活率 (OS).
- 多变量分析表明ECOG 2+和HER2转换从低到零的操作系统较差.
结论:
- 包括HER2-low在内的五个配置文件分类,可以更准确地评估转移性BC的潜在治疗变化.
- 这种精细的分类有助于理解生存差异和指导治疗决策.
更多相关视频
09:42Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
Published on: June 26, 2019
8.7K
07:00Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
Published on: September 26, 2016
16.3K
相关概念视频
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K