余力增强没有改变,而力压抑在老年时在细胞水平上被放大
Binta S Njai1, Avery Hinks1, Makenna A Patterson1
1Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, ON, Canada, N1G 2W1.
The Journal of experimental biology
|December 17, 2024
概括
较老的老鼠在细胞水平上表现出放大残余力抑制 (rFD),表明与年龄相关的肌肉变化发生在肌肉纤维内. 余力增强 (rFE) 保持不变,这表明与年龄相关的rFE修改的上游机制.
科学领域:
- 肌肉生理学 肌肉生理学
- 骨肌肉生物学 骨肌肉生物学
- 衰老的研究研究.
背景情况:
- 剩余力增强 (rFE) 和剩余力抑制 (rFD) 是依赖于历史的肌肉力特性.
- 年长的成年人表现出更大的历史依赖于联合层面的力量.
- 肌肉力量史依赖的年龄相关放大细胞基础尚不清楚.
研究的目的:
- 研究rFE和rFD的细胞机制中的与年龄相关的差异.
- 为了确定是否放大了历史的力量依赖老年起源于单个肌肉纤维水平.
- 在与年龄相关的力量调节中区分细胞贡献与建筑因素.
主要方法:
- 从年轻和老的F344BN大鼠中分离出单个psoas主要肌肉纤维.
- 经过化学透的纤维经受到了受控的缩短 (对于rFD) 和延长 (对于rFE) 收缩.
- 力量测量与在标准化骨长度下的同度参考收缩进行了比较.
主要成果:
- 在老纤维中,同位力较低,但在不同年龄组之间,特定力没有差异.
- 在老老鼠的肌肉纤维中,残余力压力 (rFD) 显著增加 (∼33%).
- 余力增强 (rFE) 在年轻肌肉纤维和老肌肉纤维之间没有差异.
结论:
- 在老老鼠中,残余力抑郁 (rFD) 在细胞水平上被放大.
- 余力增强 (rFE) 的年龄相关变化可能发生在单个肌肉纤维的上游.
- 这些发现突出了与年龄相关的肌肉力量调节变化的细胞机制.
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