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Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
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葡萄糖皮质类药物通过HNF1在胰腺β细胞中减少Slc2a2 (GLUT2) 基因表达

Yuka Ono, Kohsuke Kataoka

    Journal of molecular endocrinology
    |December 17, 2024
    PubMed
    概括

    葡萄糖皮质类药物,像德克萨米他一样,通过抑制HNF1α/HNF1β转录因子,减少胰腺β细胞中的Slc2a2基因表达. 这揭示了葡萄糖皮质类药物诱导的糖尿病和β细胞功能障碍的机制.

    关键词:
    这就是 HNF1 的原因.基因调节 基因调节 基因调节葡萄糖皮质类药物葡萄糖输送器 2 2 葡萄糖输送器胰腺β细胞是什么

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