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减肥手术或低热量饮食后8周和52周,胰岛素敏感性和肠道的变化
Adam C Lowe1, Dorien Reijnders1, Charmaine S Tam1,2
1Human Translational Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Clinical obesity
|December 17, 2024
概括
腹部外科手术在手术后一年显著改善了胰岛素敏感性和食欲感觉,与低热量饮食不同. 这些代谢益处,包括肠道变化,主要与通过手术实现的大量体重减轻有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 腹部外科 腹部外科
背景情况:
- 减肥干预措施,包括减肥手术 (BS) 和低热量饮食 (LCD),影响心脏代谢健康和胰岛素敏感性.
- 这些干预措施的精确内分泌机制和长期影响仍然不完全理解.
研究的目的:
- 为了比较胰岛素敏感性和血肠道度在BS后8周和1年后的变化,与LCD相比.
- 评估BS和LCD对主观食欲感觉的影响.
主要方法:
- 一项前性观察性研究,涉及19名肥胖的女性患者,分为BS (胃绕道或袖子胃切除术) 和LCD组.
- 通过高胰岛素-高血糖评估胰岛素敏感性;在混合饮食耐受性测试中测量血葡萄糖,胰岛素和肠道.
- 在基线,8周和1年时使用视觉模拟尺度 (VAS) 评估主观食欲.
主要成果:
- 全身胰岛素敏感性在8周后没有变化,但在BS后1年显著增加 (33.8%的体重减轻),在LCD后保持不变 (3.7%的体重减轻).
- 与LCD相比,BS与LCD相比,食后PYY增加,格林减少更多.
- 与LCD相比,BS导致饥饿感降低,腹感增加.
结论:
- 减肥手术后一年,胰岛素敏感性得到改善,与显著的体重减轻和肠道的有利变化相关.
- 在BS之后心脏代谢健康的改善主要与所达到的减肥程度有关.
- 减肥手术对胰岛素敏感性和食欲调节的影响比低热量饮食更明显和持续.
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