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宝希尼亚Pulchella提取物部分的抗微生物和抗炎活性

Jarbas Lima de Carvalho¹, Horlando Carlota da Silva², Gilvandete Maria Pinheiro Santiago³

¹Department of Pharmaceutical Sciences, Federal University of Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil.

Chemistry & biodiversity

|December 17, 2024

概括

这项研究揭示了Bauhinia pulchella干部部分具有显著的抗微生物和抗炎性质. 这些植物性化合物显示出对抗细菌和真菌感染以及减少炎症标志物的潜力.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
微生物学微生物学

背景情况:

波希尼亚·普尔切拉·本特 (Benth). 是一种具有传统药用用途的植物.
研究其生物活性化合物可以导致新的治疗剂.

研究的目的:

为了评估Bauhinia pulchella茎提取物部分的抗微生物和抗炎活性.
为了描述活性分量的化学成分.

主要方法:

使用柱式吸附色谱来分离乙醇提取物.
气色谱-质谱学 (GC-MS) 描述了J1 () 和J2 (二甲) 分数.
通过MIC和MLC测定来评估抗菌活性,通过棋盘方法确定协同作用. 在体外抗炎试验中,使用RAW 264.7巨细胞测量氧化 (NO),TGF-β和TNF-α.

主要成果:

分数J1和J2对P.aeruginosa,S.cholerasuis,Candida spp.,S.epidermidis和S.aureus具有抗菌活性.
当分离物与塞法列辛,诺弗洛克萨辛,珍塔米辛和聚米辛相结合时,观察到协同的抗菌效应.
这两种成分在体外显著降低了TNF-α,NO和TGF-β水平,以剂量依赖的方式.

结论:

富含烯和类固醇的Bauhinia pulchella干分,表现出强大的抗微生物和抗炎作用.
这些发现支持巴希尼亚的民族植物学用途,并表明其作为新型治疗化合物的来源的潜力.
与抗生素的协同效应突出显示了组合疗法的潜力.

关键词:

波希尼亚果 (Bauhinia pulchella) 是一种植物.抗微生物活性的抗微生物活性.它具有抗炎活性,具有抗炎活性.类固醇类固醇是什么化物是一种化物.

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