口服硫酸盐片和2L-聚乙烯糖醇与甲酸用于肠道制备的有效性:一个前性的随机化KASID多中心试验
Yunho Jung1, Hyun Gun Kim2, Dong-Hoon Yang3
1Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
Journal of Korean medical science
|December 17, 2024
概括
口服硫酸盐片 (OSTs) 与2L-聚乙烯糖醇加上酸 (2L-PEG/ASC) 相比,表现出不劣的肠道清洁效果. 此外,OST也显示了更好的耐受性和患者愿意重复手术的意愿.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服硫酸盐片 (OSTs) 结合了口服硫酸盐溶液和simethicone用于肠道制备.
- 这项研究评估了OST与2L-聚乙烯糖醇加上皮酸 (2L-PEG/ASC) 相比.
研究的目的:
- 为了比较OSTs的疗效,耐受性和安全性与2L-PEG/ASC用于结肠镜肠道制备.
主要方法:
- 一个前性的,随机的,受控的,单盲的,多中心的,非劣等性试验.
- 211名健康成年人接受了OST或2个L-PEG/ASC,分为两种治疗方案.
- 通过波士顿肠道制备量表 (BBPS) 和哈尔菲尔德清洁量表 (HCS) 评估肠道清洁.
主要成果:
- 在所有结肠片段中,OST显示总BBPS得分显著提高,清洁率高.
- 在OST和2个L-PEG/ASC (BBPS和HCS) 之间,整体成功清洗率没有显著差异.
- OST表现出明显更好的味道,易于消费,并愿意重复程序;不良事件是相似的.
结论:
- 口服硫酸盐片 (OST) 对于结肠镜检查肠道准备的2L-PEG/ASC没有劣势.
- 与2L-PEG/ASC相比,OSTs具有更好的耐受性和患者接受度.
- OST代表了有效和耐受性良好的肠道清洗的可行替代方案.
相关概念视频
Drugs Affecting GI Tract Motility: Other Laxatives
166
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
166
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
186
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
186
Drugs for Treatment of Ulcerative Colitis in IBD
119
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
119
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
48
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
48
Drugs for Treatment of Constipation-Predominant IBS
133
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
133
Prevention of Further Absorption of Poison
782
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
782


