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鉴定与免疫检查点抑制剂相关的胃肠道免疫相关不良事件的危险因素
Ryo Morikawa1,2, Kentaro Nitta3, Shuntaro Yasuda3
1Department of Clinical Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
胃肠道 (GI) 癌症可能会增加患免疫疗法导致的胃肠道免疫相关不良事件 (irAEs) 的风险. 生殖尿道 (GU) 癌症与更严重的GI-irAEs有关,影响生存结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 胃肠道 (GI) 毒性是与免疫检查点抑制剂 (ICI) 相关的常见和严重的免疫相关不良事件 (irAEs).
- 在接受ICI的患者中,关于GI-irAEs的风险因素的数据有限.
研究的目的:
- 在接受ICI治疗的患者中识别GI-irAEs的风险因素.
- 研究特定癌症类型与GI-irAEs的发病率和严重程度之间的关联.
主要方法:
- 在2020年1月至2022年1月期间,对361名患有各种恶性瘤的患者进行了回顾性分析,这些患者接受了ICI治疗.
- GI-irAEs定义为腹发作;单变量分析用于探索与患者特征的关联.
- 无事件生存率 (EFS) 分析与癌症类型和GI-irAEs相关.
主要成果:
- 在8.03%的患者中发生了GI-irAEs;3.88%的患者经历了≥2级的GI-irAEs.
- 与非肠道癌患者相比,肠道癌患者的EFS较短 (p=0.0275).
- 与非GU癌症患者相比,患有生殖尿路 (GU) 癌症的患者表现出更高的GI-irAEs发病率 (OR=3.26,p=0.0497) 和更短的EFS (HR=3.07,p=0.0273).
结论:
- 胃肠道癌可能是发展GI-irAEs的危险因素.
- GU癌症可能使患者易患更严重的 (≥ 2 级) GI-irAEs.
- 识别这些风险因素可以为ICI相关毒性的临床管理提供信息.
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