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在系统层面调节BRD4 PROTACs的功效,使用氨基酸合反应

Andrew McGrath1, Haiyan Huang1, Jean-Francois Brazeau2

  • 1Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48104, United States.

Journal of medicinal chemistry
|December 17, 2024
PubMed
概括

这项研究探讨了新的化学反应,以创建蛋白质分解向嵌合体 (PROTACs),以增强蛋白质降解. 新的PROTACs显示了更好的疗效,突出了治疗开发的系统化学.

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