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胚胎移植当天的血清孕激素水平不是冷解胚胎移植结果与欧卵母细胞移植的可靠预测指标:回顾性队列研究
Wenjun Chen1, Yiyao Xu1, Xinyan Liu1
1Reproductive Medical Center, The First Affiliated Hospital of SunYat-Sen University, Guangzhou, China.
BJOG : an international journal of obstetrics and gynaecology
|December 17, 2024
概括
胚胎移植当天的血清孕激素水平不能预测人工冷解周期中的活产率. 其他因素,如胚芽细胞日和胚胎质量,是成功的更重要的预测因素.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 胚胎学 胚胎学
背景情况:
- 孕激素对于怀孕的建立和维持至关重要.
- 在一些生育治疗中监测血清孕激素水平,但它们在使用肌内孕激素的人工冷解周期中的预测价值尚不清楚.
研究的目的:
- 为了确定胚胎转移 (ET) 日的血清孕激素 (P4) 水平与人工冷解转移周期中的活产率 (LBR) 是否相关.
- 确定与LBR增加相关的血清P4的潜在值.
主要方法:
- 追溯性队列研究,对761名接受单个欧囊胚胎细胞移植的患者进行了研究.
- 血清P4水平与LBR,临床怀孕率 (CPR) 和早期怀孕丧失 (EPL) 率相关分析.
- 使用多变量逻辑回归来评估血清P4与怀孕结果之间的关联.
主要成果:
- 总体而言,LBR是55.72%. 这是55.72%. 血清P4水平在活产和非活产组之间没有显著差异.
- 在ET日的血清P4水平与LBR,CPR或EPL没有独立相关.
- 胚胎细胞日 (D5与D6) 和胚胎质量独立地与LBR相关.
结论:
- 在胚胎移植日的血清孕激素水平在使用肌内孕激素时,不能预测人工冷解周期的活产率.
- 胚胎细胞发育日和胚胎质量是这些周期中活产的更重要的预测因素.
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