Aerococcus urinae 尿路感染:一个病例系列
Sofia Maraki1, Viktoria Eirini Mavromanolaki2, Dimitra Stafylaki1
11Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, 71500 Crete, Greece.
Acta microbiologica et immunologica Hungarica
|December 17, 2024
概括
Aerococcus urinae是尿路感染 (UTI) 的不常见原因,主要影响老年人. 这项研究发现对常见抗生素的敏感率很高,这表明A. urinae尿路感染的有效治疗选择.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- Aerococcus urinae是尿路感染 (UTI) 的罕见原因,主要在患有并发症的老年人中发现.
- 了解A. urinae的临床特征和抗菌素耐药性模式对于有效的患者管理至关重要.
研究的目的:
- 研究由A. urinae引起的尿路感染患者的临床和微生物特征.
- 为了确定A. urinae分离物体在三年内对抗菌素敏感性模式.
主要方法:
- 尿液培养中A. urinae患者的医学和微生物学数据的回顾性分析 (2020-2022年).
- 使用矩阵辅助激光脱离子离子化时间飞行质谱法 (MALDI-TOF MS) 识别分离物.
- 通过磁盘扩散和MIC测试条进行对氏素的抗微生物敏感性测试,使用EUCAST 2024断点进行解释.
主要成果:
- 在24名患者中发现了A. urinae,平均年龄为72岁;女性的患病率略高.
- 伴随性疾病包括泌尿病,慢性肺/病,心脏病,糖尿病和痴呆症在79.2%的患者中存在.
- 对青素,阿莫西西林,美罗和万科米辛 (100%) 观察到高敏感率;对于尼托夫兰 (95.8%) 和福斯福米辛 (91.7%) 也观察到显著的敏感性.
结论:
- Aerococcus urinae感染主要影响具有重大潜在健康状况的老年人.
- 这项研究表明,A. urinae在体外对几种常用的抗生素具有很高的敏感性,包括青素,阿莫西西林,美罗和万科米.
- 需要进行进一步的研究,包括临床试验,以证实这些发现,并评估抗菌剂在治疗A. urinae尿道感染的体内疗效.
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