多发性骨髓瘤患者自杀的风险评估和预测建模
Jiaxin Shen1,2,3, Shaoze Lin1, Hongfang Tao1
1Department of Hematology, The First Affiliated Hospital of Shantou University Medical College, 515031, Shantou, P.R. China.
Journal of cancer survivorship : research and practice
|December 17, 2024
概括
多发性骨髓瘤 (MM) 患者面临更高的自杀风险. 这项研究确定了低收入和男性性别等关键风险因素,开发了早期干预预测模型,以改善幸存者的生活质量.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 心理健康 心理健康
背景情况:
- 多发性骨髓瘤 (MM) 的生存率有所改善,但患者面临严重的痛苦和自杀风险升高.
- 早期识别自杀风险对于有效干预MM患者至关重要.
研究的目的:
- 为了研究多发性骨髓瘤患者的自杀风险因素.
- 开发一种用于识别高风险个体的预测模型.
主要方法:
- 从SEER数据库 (2001-2020年) 中分析了83333个MM个案.
- 随机分组分成培训和验证组.
- 使用C指数,ROC曲线和校准曲线开发和验证nomogram.
主要成果:
- 总共有89名MM患者因自杀而死亡,这一比例明显高于一般人群 (SMR=2.186).
- 自杀风险的关键预测因素包括低家庭收入 (≤5万美元),男性性别和年龄 (≥80岁).
- 确定的其他危险因素包括未婚状态,黑人种族和2007年后的诊断.
结论:
- 在MM患者中确定了关键的自杀风险因素.
- 开发了一种预测性名谱,以帮助医生早期识别有风险的个体.
- 该模型促进了及时采取预防措施,提高了MM幸存者的生活质量.
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