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相关概念视频

Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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相关实验视频

Updated: Jun 4, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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内耳毛细胞中的条件Tnfaip6-Knockout不会改变听觉功能

Yue Qiu1, Song Gao1, Xiaoqiong Ding2

  • 1Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Neuroscience bulletin
|December 17, 2024
PubMed
概括

瘤亡因子α诱导蛋白6 (TNFAIP6) 对听觉系统没有显著影响. 对Tnfaip6淘汰赛小鼠的研究发现,即使在杂的环境中,听力或毛细胞功能也没有变化.

关键词:
在Tnfaip6中使用.头发细胞 头发细胞 头发细胞听力损失 听力损失噪声 噪声 噪声

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Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
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Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
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相关实验视频

Last Updated: Jun 4, 2025

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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科学领域:

  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 噪音引起的听力损失是与炎症相关的全球重大健康问题.
  • 瘤亡因子-α (TNFα) 和其相关蛋白质 (TNFAIPs) 与耳损伤有关.
  • TNFAIP6在内耳中的作用及其对听力的影响在很大程度上仍未被描述.

研究的目的:

  • 调查TNFAIP6在听觉系统中的特定功能.
  • 为了确定TNFAIP6是否在防止噪音引起的听力损失方面发挥作用.
  • 阐明TNFAIP6在耳炎症和损伤中的机制.

主要方法:

  • 为Tnfaip6 (Tnfaip6 cKO) 生成条件淘汰赛小鼠模型.
  • 评估毛细胞形态和丝带突触完整性的评估.
  • 在标准环境和杂环境中评估听力功能.

主要成果:

  • 在Tnfaip6 cKO和野生型小鼠之间没有观察到毛细胞数量或形态的显著差异.
  • 在没有Tnfaip6.6的情况下,丝带突触完整性保持不变.
  • 即使在暴露于噪音的情况下,Tnfaip6缺乏也没有影响听觉敏感性和毛发细胞功能.

结论:

  • 在听觉系统的正常功能或保护中,TNFAIP6似乎没有发挥实质性的作用.
  • 该研究表明,TNFAIP6不是缓解噪音引起的听力损伤的关键因素.
  • 可能需要进一步的研究来探索其他TNFAIP家族成员或听力健康的替代途径.