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在天然的骨哺乳动物中,转变核蛋白和原蛋白的同进化和适应支持了黑女王假设

Simin Chai¹, Jieqiong Kang², Tianzhen Wu²

¹Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, Guangdong, China.

Genome biology and evolution

|December 17, 2024

概括

精子核蛋白质,原蛋白质 (PRM) 和过渡核蛋白质 (TNPs) 在没有下降丸的哺乳动物中进化出了独特的策略. PRM2和TNP2的基因损失,与增强的PRM1和TNP1功能,有助于精子发育在ascrotal物种.

科学领域:

进化生物学是进化的生物学.
分子生物学分子生物学
生殖生物学生殖生物学

背景情况:

质氨酸 (PRM) 和过渡核蛋白 (TNPs) 对于精子染色质的凝聚和功能至关重要.
阴囊哺乳动物的密囊症 (未下降的丸) 会损害精子质量,但具有自然未下降的丸的阴囊哺乳动物会产生正常的精子.

研究的目的:

研究具有不同丸位置的哺乳动物中PRM和TNP的进化模式和功能变化.
探索自然体哺乳动物精子生成的分子机制.

主要方法:

在哺乳动物物种中对PRM和TNP基因进行比较基因组分析.
功能性评估PRM1和TNP1蛋白质的特性 (热可变性,DNA结合,DNA修复).

主要成果:

在哺乳动物中观察到的PRM和TNP基因的保存基因组排列.
完整的PRM2和TNP2基因的共同进化损失与几个物种的丸位置相关.
没有完整的PRM2和TNP2的鱼显示出增强的PRM1热稳定性/DNA结合以及优越的TNP1DNA修复能力.

结论:

在PRM2和TNP2的基因损失,加上PRM1和TNP1的功能增长,代表了进化的适应性,以自然密码化在ascrotal哺乳动物.
这种策略增强了精子染色质凝聚和DNA修复,支持精子在具有挑战性的生理条件下发挥作用,并与黑女王假说保持一致.

关键词:

体哺乳动物的体蛋白质胺是一种蛋白质胺.黑女王假设是黑女王的假设.过渡期核蛋白质过渡期核蛋白质

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