丰坦患者的白发病率:系统性审查和元分析
Hannah Van Belle1, Jef Van den Eynde1, Aleksandra Cieplucha1,2
1Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Pediatric cardiology
|December 17, 2024
概括
蛋白尿,损伤的标志物,在Fontan循环患者中很常见. 这种尿白蛋白与肌素比率 (UACR) 的升高比降低的淋巴膜过率 (GFR) 更为普遍,这表明UACRR更为普遍.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 儿童心脏病学 儿童心脏病学
背景情况:
- 患有Fontan循环的患者面临慢性病 (CKD) 的风险增加.
- 慢性瘤是由减少的淋巴膜过率 (GFR) 或尿白蛋白与肌素比率 (UACR) 的升高来定义的.
研究的目的:
- 为了确定Fontan循环患者中白蛋白尿的患病率.
- 评估该人群中白蛋白尿症的临床决定因素.
主要方法:
- 来自MEDLINE,EMBASE,Trip和Cochrane数据库的研究的系统审查和元分析.
- 纳入标准:研究报告了Fontan患者的专性尿素患病率;排除标准:病例报告,综述,Fontan前或心脏移植后的患者.
- 用于元分析的质量效应模型;执行偏差评估.
主要成果:
- 在11项研究 (873名患者) 中,专尿的综合患病率为28.4% (95% CI 23.5-33.5%).
- 在被研究的患者中,淋巴膜过率 (GFR) 一般保持不变.
- 在5项研究中,白膜尿显示与系统静脉压升高有关;其他关联是不确定的.
结论:
- 在Fontan循环患者中,白蛋白尿比降低的GFR更为普遍.
- 尿中的白蛋白与肌素比率 (UACR) 可能是这个人群中CKD的有价值的查工具,除了GFR.
- 限制包括主要的回顾性/横截面设计和小,异质的研究群体.
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