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下肢外周动脉疾病的终身风险:丹麦全国纵向研究

Mette Søgaard¹, Christian-Alexander Behrendt^2,3, Nikolaj Eldrup⁴

¹Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg University Hospital, Selma Lagerløfs Vej 249, 9260 Gistrup, Denmark.

European heart journal

|December 17, 2024

概括

超过11%的丹麦人面临周围动脉疾病 (PAD) 的终身风险,这种疾病与显著的发病率和死亡率有关. 这种风险随着时间的推移而下降,但对于男性和社会经济地位较低的人来说仍然更高.

科学领域:

血管医学血管医学
流行病学流行病学
公共卫生公共卫生

背景情况:

周围动脉疾病 (PAD) 在全球范围内构成重大健康负担.
对PAD的终身风险估计尚未得到充分确立.
了解PAD发病率和结果对于公共卫生规划至关重要.

研究的目的:

在丹麦人口中量化发展PAD的终身风险.
分析PAD诊断后的临床结果,包括再血管化,截肢和死亡率.
根据性别和社会经济地位调查PAD风险和结果的差异.

主要方法:

丹麦的一项全国性队列研究,涉及4,275,631名年龄在40-99岁之间的个人 (1998-2018).
利用修改后的生存分析来估计终身风险,同时考虑死亡等竞争风险.
为了评估结果,研究人员对参与者进行了平均15.5年的跟踪.

主要成果:

从40岁开始,PAD的整体终身风险为11.6%,从1998-2002年到2013-2018年有所下降.
男性 (12.8%) 的终身风险高于女性 (10.5%).
在PAD风险,重大截肢和死亡率中观察到显著的社会经济梯度,但不是再血管.

结论:

超过10%的丹麦人一生中被诊断出患有症状的PAD.
患有PAD的诊断与相当大的1年和5年的发病率 (再血管,截肢) 和死亡率有关.
社会经济地位强烈影响PAD诊断后的主要截肢和死亡风险.

关键词:

流行病学流行病学终身风险终身风险终身风险周围动脉疾病周围动脉疾病人口人口的人口人口.

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