肺栓塞在患有菌性肺炎的儿童:它可以预测吗?
Jiapu Hou1,2, Ruiyang Sun1,2, Xue Zhang1,2
1Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 450052, China.
概括
儿科 Mycoplasma pneumoniae 肺炎 (MPP) 与肺栓塞 (PE) 可能出现不寻常的症状. D-二聚合物,IL-6,CRP和LDH水平升高可能表明MPP儿童患PE的风险较高.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
背景情况:
- 菌性肺炎肺炎 (MPP) 是一个常见的儿童呼吸道感染.
- 肺栓塞 (PE) 是一种严重的并发症,可能发生在儿童中MPP.
- 了解联合MPP和PE的临床特征对于早期诊断和管理至关重要.
研究的目的:
- 调查儿科Mycoplasma pneumoniae肺炎 (MPP) 复杂的肺栓塞 (PE) 的临床特征.
- 确定潜在的生物标志物来预测MPP儿童的PE.
主要方法:
- 对291例患有MPP的住院儿科病例进行了回顾性研究.
- 病例被分为PE组 (141) 和非PE对照组 (150).
- 分析了临床数据,包括实验室标志物和症状,并在各组之间进行了比较.
主要成果:
- 与非PE组相比,PE组的C-反应蛋白 (CRP),D-二聚体,乳酸脱酶 (LDH) 和IL-6 (IL-6) 含量显著更高.
- 对于PE预测的关键指标包括D-二次体 (AUC=0.964),LDH (AUC=0.765),CRP (AUC=0.690) 和IL-6 (AUC=0.632).
- 在63.12%的PE组中观察到肺性亡,同时还注意到血和胸痛.
结论:
- 患有PE的儿科MPP可以表现为非典型的临床症状.
- D-二聚合物,IL-6,CRP和LDH水平升高与MPP儿童PE风险增加有关.
- 这些发现有助于识别高风险儿科患者,以便及时诊断和干预PE.
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