在下肢手术后,普雷尼索隆和普雷加巴林对治疗持续性刺伤后头痛的止痛效果进行比较研究
Dina Abdelhameed Elsadek Salem1, Mahmoud M Elnady2, Sherif A Alagamy3
1Departments of Anesthesia, Intensive Care, and Pain Management, Faculty of Human Medicine, Zagazig University Alsharkia, Egypt.
Pain physician
|December 17, 2024
概括
口服普雷加巴林和普雷迪尼索隆在脊髓麻醉后有效地管理疼痛后刺痛头痛 (PDPH). 与普雷尼索隆相比,普雷加巴林表现出优异的疼痛减缓,为PDPH提供了有前途的治疗方法.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 持续刺穿后头痛 (PDPH) 是脊髓麻醉后的一个显著并发症.
- 目前PDPH的管理策略缺乏明确的疗效,需要研究新的治疗方法.
研究的目的:
- 为了比较口服普雷迪尼索隆与口服普雷加巴林在治疗PDPH中的止痛效果.
- 为了评估这些治疗对头痛严重程度,救援止痛和外周周周血补丁需求的影响.
主要方法:
- 一项前性,双盲,随机对照研究,涉及63名下肢手术后患有PDPH的患者.
- 患者被分配接受保守治疗,普雷迪尼索隆加保守治疗或普雷加巴林加保守治疗.
- 主要结局包括视觉模拟量表 (VAS) 和修改后的Lybecker分数;次要结局是救援止痛,外围血贴 (EBP) 要求和不良反应.
主要成果:
- 普雷尼索隆和普雷加巴林组在12小时和24小时后,与对照组相比,头痛强度显著降低.
- 普雷加巴林组在12小时和24小时显示出比普雷迪尼索隆组更低的头痛强度.
- 普雷加巴林组的基托洛拉克消耗量低于普雷迪尼索龙组,普雷迪尼索龙组或普雷加巴林组的任何患者都不需要 epidural 血液贴片.
结论:
- 口服的普雷迪尼索隆和普雷加巴林有效地减轻了PDPH的严重程度.
- 口服普雷加巴林在治疗PDPH方面表现出比口服普雷迪尼索隆更高的疗效.
- 需要进一步研究更大的样本大小来概括这些发现.
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