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Updated: Jun 4, 2025

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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基于细菌和细菌衍生物的药物输送系统:一种用于治疗中枢神经系统疾病的新方法

Shizhu Gao1, Xin Li2, Bing Han1

  • 1Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, PR China.

Expert opinion on drug delivery
|December 17, 2024
PubMed
概括

工程细菌及其组成部分显示出精确的药物输送穿过血脑屏障 (BBB) 治疗中枢神经系统 (CNS) 疾病的希望. 未来的进展重点是人工智能和个性化医学,解决安全性和可扩展性挑战.

关键词:
通过细菌介导的药物输送.大脑向的分娩化学反应的化学作用.智能药物输送系统是一个智能药物输送系统.目标化机制的目标化机制.

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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