后消化奖励通过行为强化作用,在肥胖和减肥手术后保持
Gabriela Ribeiro1,2, Ana B Fernandes1,3, Francisco P M Oliveira1
1Champalimaud Research & Clinical Centre, Champalimaud Foundation, Av. de Brasília, Doca de Pedrouços, Lisboa, Portugal.
PLoS biology
|December 17, 2024
概括
营养素摄入量通过多巴胺通路塑造食物偏好,这种过程在肥胖和减肥手术后得到保留. 这个大脑机制影响饮食行为和饮食学习.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 营养科学 营养科学
背景情况:
- 消化后的营养摄入会影响食物偏好.
- 大脑中的多巴胺通路与奖励和学习有关.
- 肥胖与改变大脑对食物线索的反应有关.
研究的目的:
- 为了研究后性营养刺激如何影响食物偏好.
- 检查状多巴胺在风味营养条件 (FNC) 中的作用.
- 为了比较健康个体,肥胖个体和腹腔外科手术后患者的FNC.
主要方法:
- 使用富含马尔托德氨酸的酸奶进行调味营养制剂 (FNC).
- 评估食物摄入量和愉快度等级.
- 使用[123I]IBZM SPECT测量条状多巴胺D2类受体 (DD2lR) 的可用性.
主要成果:
- 健康的志愿者增加了对营养配对风味的偏好,这取决于摄入量,而不是愉快度.
- 在所有组 (肥胖症,后腹症,对照组) 中都证实了行为调节,没有乐趣的群体差异.
- 肥胖组的DD2lR可用性降低与空调强度和胃旁路术后节制饮食相关.
结论:
- 后消化营养刺激通过行为强化影响食物选择.
- 这种营养条件机制在肥胖和减肥手术后仍然存在.
- 状多巴胺基神经递质在饮食学习中起作用,并且在肥胖中发生变化.
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