多个独立的遗传代码重新分配的UAG停止码在状状动物中
Jamie McGowan1, Thomas A Richards2, Neil Hall1,3
1Earlham Institute, Norwich Research Park, Norwich, United Kingdom.
PLoS genetics
|December 17, 2024
概括
毛动物的遗传代码令人惊地灵活. 研究人员发现UAG编码子,通常是停止信号,用于编码氨基酸,如白氨酸和谷氨酸在多个独立的事件内Phyllopharyngea.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 进化生物学 进化生物学
背景情况:
- 遗传密码在整个生命中高度保存,氨基酸和停止信号的标准编码.
- 类动物 (原生动物) 是已知的例外,它们表现出不同的遗传代码变异和进化变化.
- 标准的遗传密码使用61个代码为20个氨基酸和3个停止代码 (UAA,UAG,UGA).
研究的目的:
- 为了研究状动物的Phyllopharyngea类内的遗传密码变异.
- 发现独立的遗传代码变化及其机制.
- 了解微生物真核生物中的遗传密码的进化性.
主要方法:
- 挖掘公开可用的状动物基因组数据集 (TARA海洋).
- 识别新的抑制性tRNA基因.
- 对未培养和已发表的状动物基因组进行了基因组学分析.
主要成果:
- 在三种独立的毛动物物种中发现UAG密码子重新分配到白.
- 将UAG解码为氨酸的抑制器tRNAs的识别.
- 在Hartmannula sinica和Trochilia petrani中检测UAG重新分配到谷氨酸,表明两个独立的事件.
- 遗传学分析证实了单体系的血统和独立的进化事件.
- UAA仍然是一个固定的停止编码子,而UAG在Phyllopharyngea中被广泛用作感觉编码子.
结论:
- 在Phyllopharyngea ciliates中发生了涉及UAG编码的多个独立的遗传代码变化.
- 在这个群体中,重新分配的UAG编码子被广泛用作感觉编码子.
- 这些发现凸显了未被充分研究的微生物真核生物中遗传密码的动态性和可变性.
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